We could not find any study evaluating the MPV levels in GAD patients in the literature. MPV values were studied in also schizophrenia, bipolar disorder and panic disorder with contradictory and inconclusive results. Increased MPV levels are thought to be closely related to cardiovascular disorders.
Mean platelet volume (MPV), which is indicative of platelet size, is accepted as an indication of platelet activity.
In addition, treatment with selective serotonin reuptake inhibitors may lead to a decrease in platelet activity. Plasma platelets have the ability of synthesis, release and reuptake of serotonin similar to neurons in the central nervous system. It is accepted that serotonin which plays an important role in anxiety disorders is also an important factor in determining vascular tone and platelet aggregation. Increased catecholamine levels are thought to increase thrombosis by causing an increase in platelet activity and sympathoadrenal activation is thought to stimulate platelets through the α-2 receptors, resulting in an increase in platelet volume and activity. Stressful life events and anxiety usually elevate circulating levels of blood catecholamines. Anxiety disorders related “peripheral changes” are considered to be a cumulative sign of the total central nervous system activity. The exact mechanism of increased platelet activity after mental stress remains unclear. suggested that anxiety increased the risk of developing coronary artery disease by 26% when other medical conditions were controlled. On the other hand, anxiety symptoms in patients with coronary artery disease have been shown to be more effective in increased platelet activity than depression. Increased platelet activity has been detected in patients with major depression with a history of myocardial infarction and also in patients without any other risk factors effecting platelet activity.
It also aggravates physical diseases especially cardiovascular disorders. Major depressive disorder is a common companion to GAD beside increased rates of alcohol and substance abuse. GAD patients are more likely to be encountered at primary health care facilities with non-specific complaints such as headache, muscle stiffness, gastrointestinal complaints, back pain and insomnia. The lifetime prevalence is thought to be between 5.7% and 14.2%. Generalized anxiety disorder (GAD) is characterized by persistent and chronic anxiety state that lasts for at least 6 months which takes place in multiple areas of life. We believe that further controlled prospective studies about this issue will be valuable. According to ROC curve analysis for differentiation of GAD from those in the control group, MPV would be considered to be a “poor” biochemical marker. This finding is consistent with the non-linear inverse relation between platelet volume and platelet count. Also platelet levels were found to be significantly lower in GAD patients in our study. The area under the ROC curve (AUC) of MPV levels for GAD was 0.655 (95% CI: 0.557–0.754, p < .001).ĭISCUSSION: Increased MPV levels in GAD patients in our study supports the hypothesis of increased platelet activation due to sympathetic system activation. RESULTS: MPV was found to be significantly higher ( p = .008) and platelet count was found to be significantly lower in the GAD group ( p = .001). METHOD: In this first retrospective cohort study about MPV among GAD patients, we compared complete blood count especially in terms of platelet count (PLT), platelet distribution width (PDW), plateletcrit (PCT) and MPV values of 60 GAD patients with 60 healthy controls. Stressful life events and anxiety usually cause an increase in platelet volume and activity through various mechanisms. OBJECTIVE: Generalized anxiety disorder (GAD) is characterized by persistent and chronic anxiety state.
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